Keil, and these recommendations are given here with no substantial change.ģAA-20.2. IUB-IUPAC recommendations were approved in 1968 on the basis of proposals of a subcommittee of W. in their compilations of protein sequences (, latest edition ). systematized the idea in 1961 (see, for example, ), and Dayhoff and Eck used one-letter symbols derived partly from the code of Sorm et al. The possibility of using one-letter symbols was mentioned by Gamow & Ycas in 1958. It may also be used to label residues in three-dimensional pictures of protein molecules. A one-letter code is much more concise, and is helpful in summarizing large amounts of data, in aligning and comparing homologous sequences, and in computer techniques for these processes. There are difficulties in using the three-letter system ( 3AA-14 to 3AA-19) in presenting long protein sequences. General Considerations Regarding the One-Letter System THE NEED FOR A CONCISE REPRESENTATION OF SEQUENCEģAA-20.1. Part 2, Section B: THE ONE-LETTER SYSTEM (revision and updating of )ģAA-20.
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